Licht-im-Terrarium: Literaturdatenbank
Licht-im-Terrarium: Literaturdatenbank |
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Changaris, D. G., Lu, Z., Chen, T., & Holick, M. F. (2002). Pulsed uvb irradiation converts 7-dehydrocholesterol to previtamin d3 and photoproducts. In M. F. Holick (Ed.), Biologic Effects of Light 2001: Proceedings of a Symposium Boston, Massachusetts June 16--18, 2001 (pp. 65–74). Boston, MA: Springer US. Added by: Sarina (2021-08-22 13:37:11) Last edited by: Sarina (2021-08-23 08:15:49) |
| Resource type: Book Article DOI: 10.1007/978-1-4615-0937-0_5 ID no. (ISBN etc.): 978-1-4615-0937-0 BibTeX citation key: Changaris2002 View all bibliographic details  |
Categories: Englisch = English Keywords: Vitamin D = Vitamin D Creators: Changaris, Chen, Holick, Holick, Lu Publisher: Springer US (Boston, MA) Collection: Biologic Effects of Light 2001: Proceedings of a Symposium Boston, Massachusetts June 16--18, 2001 |
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As a first step toward documenting efficacy of the Mark IV (Synaptic Tan, Inc., Louisville, KY, synaptictan.com) for clinical vitamin D3 augmentation we sought to determine whether in vitro photoactivation of 7-dehydrocholesterol (7-DHC) occurs. The Mark IV provides uniform illumination ( ±15%) over 0.5 m2 at 60 cm utilizing non-spatial collimation with 20-100 µ pulses of UVB/UVA. The optically coated reflectors serve as highly effective bandpass filters with output ranging over 270-370 nm with little light measured above and below this range. The device delivers 1 FDA corrected MED within 1-4 minutes depending on pulse rate and distance. Glass ampoules (total 27) containing 7-DHC in methanol were exposed to 0.5, 1, and 2 MED at 30, 45, and 60 cm. Assay for preVitamin D3 (preD3), Lumisterol (L3), and Tachysterol (T3) identified a dose-dependent linear relationship for the formation of preD3 independent of distance. This confirms that "reciprocity" is preserved with 20-100 µ pulses.
Added by: Sarina Last edited by: Sarina |